Publications
Enteric nervous system and gut innervation
Shi D*, Reddy P*, Marrin M*, Walker C, Siu C, Muller PA, Yap E-L, Sharma N. 2025. Properties and functions of transcriptionally distinct enteric neurons. Cell. Vol. 188:7571-7590. *These authors contributed equally. https://doi.org/10.1016/j.cell.2025.10.041
Millett CJ, Shaver JJ, Bracken B, Jones SJ, Lovelett RJ, Rubinow DA, Singhal R, Charlton C, Piazza N, Hauck Q, Sharma N, Muller PA. 2025. In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons. Cell. Vol. 188:7547-7570. https://doi.org/10.1016/j.cell.2025.11.024
Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi S, Sharma N, Ginty DD. 2023. DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. Cell. Vol. 186:3368-3385. https://doi.org/10.1016/j.cell.2023.07.007
Somatosensory neuron diversity, development, and pain
Lezgiyeva K, Liu J, Nguyen K, DeLisle MM, Ko FC, Fullam S, Obeidat AM, Turecek J, Alkislar I, Lehnert BP, Martinez-Garcia RI, Sivakumar R, Choi J, Mazor O, Garibyan L, Sharma N, Emanuel AJ, Malfait AM, Miller RE, Ginty DD. 2026. Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses. Neuron. https://doi.org/10.1016/j.neuron.2026.06.014
Santiago C, Siegrist J, Africawala N, Handler A, Tasnim A, Anjum R, Turecek J, Lehnert BP, Renauld S, Choi J, Nolan-Tamariz M, Iskols M, Magee AR, Paradis S, Sharma N, Ginty DD. 2025. Activity-dependent development of the body's touch receptors. Neuron. Vol. 113:1758-1773. https://doi.org/10.1016/j.neuron.2025.04.015
Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo VK, Chiu IM, Ginty DD*, Sharma N*. 2024. A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell. Vol. 187:1508-1526. *Co-corresponding authors. https://doi.org/10.1016/j.cell.2024.02.006
Meltzer S, Santiago C, Sharma N, Ginty DD. 2021. The cellular and molecular basis of somatosensory neuron development. Neuron. Vol. 109:3736-3757. https://doi.org/10.1016/j.neuron.2021.09.004
Sharma N, Flaherty K, Lezgiyeva K, Wagner DE, Klein AM, Ginty DD. 2020. The emergence of transcriptional identity in somatosensory neurons. Nature. Vol. 577:392-398. https://doi.org/10.1038/s41586-019-1900-1
Sharma N*, Deppmann CD*, Harrington AW*, St Hillaire C, Chen Z-Y, Lee FS, Ginty DD. 2010. Long-distance control of synapse assembly by target-derived NGF. Neuron. Vol. 67:422-434. *These authors contributed equally. https://doi.org/10.1016/j.neuron.2010.07.018
Deppmann CD*, Mihalas S*, Sharma N*, Lonze BE, Niebur E, Ginty DD. 2008. A model for neuronal competition during development. Science. Vol. 320:369-373. *These authors contributed equally. https://doi.org/10.1126/science.1152677
Activity-dependent gene expression
Yap E-L, Pettit NL, Davis CP, Nagy MA, Harmin DA, Golden E, Dagliyan O, Lin C, Rudolph S, Sharma N, Griffith EC, Harvey CD, Greenberg ME. 2021. Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Nature. Vol. 590:115-121. https://doi.org/10.1038/s41586-020-3031-0
Sharma N*, Pollina EA*, Nagy MA*, Yap E-L, DiBiase FA, Hrvatin S, Hu L, Lin C, Greenberg ME. 2019. ARNT2 tunes activity-dependent gene expression through NCoR2-mediated repression and NPAS4-mediated activation. Neuron. Vol. 102:390-406. *These authors contributed equally. https://doi.org/10.1016/j.neuron.2019.02.007
Ataman B*, Boulting GL*, Harmin DA, Yang MG, Baker-Salisbury M, Yap E-L, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME. 2016. Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature. Vol. 539:242-247. *These authors contributed equally. https://doi.org/10.1038/nature20111
Bloodgood BL*, Sharma N*, Browne HA, Trepman AZ, Greenberg ME. 2013. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature. Vol. 503:121-125. *These authors contributed equally. https://doi.org/10.1038/nature12743
Soskis MJ, Ho HH, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. 2012. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience. Vol. 15:1645-1654. https://doi.org/10.1038/nn.3249
Earlier work
Knight JS, Lan K, Bajaj B, Sharma N, Tsai D, Robertson ES. 2006. A peptide-based inhibitor for prevention of B cell hyperproliferation induced by Epstein-Barr virus. Virology. Vol. 354:207-214.
Sharma N, Knight JS, Robertson ES. 2006. Conserved cell cycle regulatory properties within the amino terminal domain of the Epstein-Barr virus nuclear antigen 3C. Virology. Vol. 346:374-384.
Knight JS, Sharma N, Robertson ES. 2005. Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. PNAS. Vol. 102:18562-18566.
Knight JS, Sharma N, Robertson ES. 2005. SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen. Molecular and Cellular Biology. Vol. 25:1749-1763.
Lan K, Kuppers DA, Verma SC, Sharma N, Murakami M, Robertson ES. 2005. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA. Journal of Virology. Vol. 79:7453-7465.
Knight JS, Sharma N, Kalman DE, Robertson ES. 2004. A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in EBV-infected cells. Journal of Virology. Vol. 78:12857-12867.